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[14] Researchers hypothesize that ghrelin receptors play a role in appetite regulation and, when activated, might enhance hunger signals

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Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression

Over weeks and months, fat mass decreases while lean mass increases simultaneously